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Tocris Bioscience™ AP 14145 hydrochloride
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Product Code. 18799696
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5 mg
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5mg
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Description

Negative allosteric modulator of KCa2 (SK) channels

AP 14145 hydrochloride is a KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.
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Specifications

Chemical Name or Material N-[2-[[(1R)-1-[3-(Trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-7-yl]acetamide hydrochloride
CAS 2387505-59-9
Quantity 5 mg
Molecular Formula C18H17F3N4O.HCl
Purity 98%
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