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Invitrogen™ AOX1 Polyclonal Antibody
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Product Code. 16607894
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Quantity:
100 μL
Unit Size:
100µL
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16607894 100 μL 100µL
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Product Code. 16607894 Supplier Invitrogen™ Supplier No. PA5101413

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total AOX1.

AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of a variety of aldehydes, leading to the production of hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), an autosomal dominant neurodegenerative disorder characterized by the death of motor neurons in the spinal cord, brain and brainstem. Significantly, AOX1 is highly expressed in the ventral horn of the spinal cord and the gene that encodes AOX1 is located in a chromosomal region that is frequently found to be implicated in ALS2. This evidence suggests that AOX1 is a candidate gene for ALS2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AOX1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene AOX1
Gene Accession No. O54754, Q06278, Q9Z0U5
Gene Alias AI196512; AI255253; Aldehyde oxidase; aldehyde oxidase (female form); aldehyde oxidase 1; aldehyde oxidase 2; Ao; AOH1; Aox1; Aox-1; Aox2; Aox-2; Azaheterocycle hydroxylase; azaheterocycle hydroxylase 1; Moro; Retinal oxidase; Ro
Gene Symbols AOX1
Host Species Rabbit
Immunogen A synthesized peptide derived from human AOX1(Accession Q06278), corresponding to amino acid residues K525-H575.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11761, 316, 54349
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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