Invitrogen™ WHSC2 Monoclonal Antibody (6B11H8)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA517199

Product Code. 15348170

Description

MA5-17199 targets WHSC2 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Rat samples. The MA5-17199 immunogen is purified recombinant fragment of human WHSC2 (amino acids: 280-511) expressed in E. Coli. MA5-17199 detects WHSC2 which has a predicted molecular weight of approximately 57.3kDa.

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Specifications

• Antigen: WHSC2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q9H3P2
• Gene Symbols: NELFA
• Immunogen: Purified recombinant fragment of human WHSC2 (amino acids: 280-511) expressed in E. Coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 6B11H8
• Conjugate: Unconjugated
• Gene: NELFA
• Gene Alias: FLJ10442; FLJ25112; LOW QUALITY PROTEIN: negative elongation factor A; mWHSC2; Negative elongation factor A; negative elongation factor complex member A; negative elongation factor complex member A, Whsc2; Nelfa; NELF-A; P/OKcl.15; Whsc2; Whsc2h; Wolf-Hirschhorn syndrome candidate 2; Wolf-Hirschhorn syndrome candidate 2 homolog; Wolf-Hirschhorn syndrome candidate 2 protein
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 305455, 7469
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid