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  7. 15856049

TopBP1 Mouse anti-Human, Unlabeled, Clone: 33, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 611875

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Product Code. 15856049

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Description

Description

Eukaryotic DNA topoisomerase II, a ubiquitous ATP-dependent type II topoisomerase, is an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression. Topoisomerases transiently break a pair of complementary strands in double-stranded DNA to form a gate for the passage of duplex DNA. Two isoforms of DNA topoisomerase II have been identified: topo IIα and topo IIβ. These exhibit a high degree of homology, except for some divergence in the C-terminal region. Both contain multiple bipartite nuclear localization sequences (NLS) that mediate their subnuclear localization. DNA Topoisomerase II Binding Protein 1 (TopBP1) binds the C-terminal region of Topo IIβ via its N-terminal region. In addition, TopBP1 contains a putative ADP-ribosylation site, two N-terminal NLS domains, and 8 repeating BRCA1 C-terminal (BRCT) domains found in DNA repair proteins, such as BRCA1, XRCC1, and Rad4. The BRCT domains of TopBP1 have been shown to bind DNA breaks, DNA nicks, and DNA termini, but not circular intact DNA. Thus, TopBP1 may localize topoisomerases to sites of DNA damage.

Host Species: Mouse
Clone: 33
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human TopBP1 aa. 204-416

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

TopBP1
Monoclonal
250μg/mL
Topoisomerase II Binding Protein 1
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
33
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human TopBP1 aa. 204-416
150 μg
Cell Biology
Human
IgG1
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