TFE3 Mouse anti-Mouse, Unlabeled, Clone: G138-312, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 554263

Product Code. 15897628

Description

TFE3 is a ubiquitously expressed 50kDa transcription factor containing both basic helix-loop-helix (bHLH) and leucine zipper (ZIP) motifs. It was initially identified as a protein which bound to the μE3 site in the immunoglobulin heavy chain enhancer. In addition, it binds to the MLTF/USF site in the adenovirus major late promoter. Upon binding as a dimer, it induces a minor groove-oriented bend in the DNA, similar to other HLH proteins such as TFEB, USF, myc, and max. Binding results in transcriptional activation and is mediated through the basic region located just N-terminal to the HLH domain. Clone G138-312 recognizes TFE3. The antibody was raised against a bacterially expressed TFE3-L protein consisting of 327 amino acids encoded by nucleotides 361-2469 of the cloned cDNA.

Host Species: Mouse
Clone: G138-312
Isotype: IgG1
Species Reactivity: Human
Immunogen: TFE3-L Protein
Formula Weight [Chemical]: 50kDa

Immunoprecipitation, Western Blotting

Specifications

• Antigen: TFE3
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: TFE3-L Protein
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse
• Isotype: IgG1

• Applications: Western Blot
• Clone: G138-312
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.