anti-TCR V beta 13.1 FITC, Clone: H131, Invitrogen™

TCR V beta 13.1 Monoclonal antibody A18459 from Invitrogen specifically detects TCR V beta 13.1 in Human samples. It is validated for Flow Cytometry.

Brand:  Invitrogen A18459

Product Code. 15454693

Description

TCR V beta 13.1 Monoclonal antibody A18459 from Invitrogen specifically detects TCR V beta 13.1 in Human samples. It is validated for Flow Cytometry.

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha variable and joining genes. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Ten variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG2b, κ
Clone: H131
Immunogen: Human TCR V beta 13.1 Protein
Formulation: 25 Tests Purified Antibody (0.2mg/ml) in proprietary buffer, with 0.09% sodium azide
Synonyms: TCR Vb13.1, TCRV beta-13.1
This product detects TCR V beta 13.1 in Human samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Human TCR V beta 13.1 Protein.

Specifications

• Antigen: TCR V beta 13.1
• Classification: Monoclonal
• Conjugate: FITC
• Gene Alias: TCR Vb13.1, TCRV beta-13.1
• Immunogen: Human TCR V beta 13.1 Protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4° C
• Isotype: IgG2b κ

• Applications: Flow Cytometry
• Clone: H131
• Formulation: 25 Tests Purified Antibody (0.2mg/ml) in proprietary buffer, with 0.09% sodium azide
• Host Species: Mouse
• Quantity: 25 Tests
• Target Species: Human
• Form: Purified