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Tau Mouse anti-Bovine, Human, Clone: HT7, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MN1000

Code : PN

Additional Details : CAS Number : 173282-60-5 Weight : 0.68040kg

Product Code. 11824351

  • £288.00 / 100µg


EU Stock 20
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Description

Description

Tau is a neuronal microtubule-associated protein found predomitly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer′s diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick′s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Specifications

Specifications

Tau
Monoclonal
0.2 mg/mL
PBS with no preservative
P29172, P10636
G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau
Mouse
IgG1, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
281296, 4137
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
HT7
Unconjugated
MAPT
Liquid
MAPT
Purified human Tau, epitope human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK.
Protein A
RUO
Antibody
Monoclonal
Bovine, Human
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