Syntaxin 1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA529765

Product Code. 13404037

Description

Recommended positive controls: U87-MG, SK-N-SH, IMR32, SK-N-AS, mouse brain, rat brain. Predicted reactivity: Mouse (99%), Rat (99%), Rhesus Monkey (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Syntaxin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Stx1a
• Gene Alias: HPC-1; LOW QUALITY PROTEIN: syntaxin-1A; neuron-specific antigen HPC-1; P35-1; P35A; Sap; STX1; Stx1a; STX1B; STX1B1; STX1B2; STXA1; SYN1A; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A; syntaxin 1A (brain); syntaxin 1A (brain)-like; syntaxin-1A; Syntaxin-1B1; Syntaxin-1B2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116470, 20907, 6804
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.28 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O35526, P32851, Q16623
• Gene Symbols: Stx1a
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 195 of Human Syntaxin 1A
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG