Syk Mouse anti-Human, Clone: 8H5, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA517206

Product Code. 15378170

Description

A suggested positive control for this product is THP-1 cells.

Syk, Spleen tyrosine kinase, is expressed in a wide range of hematopoietic and non-hematopoietic cells and plays a key role in adaptive immune system, which is the immunoreceptor (B cell receptor and Fc-receptors) signaling pathways including Fcgamma receptor-mediated phagocytosis. In hematopoietic cells such as B and T lymphocytes, natural killer cells, mast cells, macrophages and platelets, Syk is involved in the proximal signaling downstream of activated immunoreceptors (e.g. BCR, TCR, Fc receptors) containing immunoreceptor tyrosine-based activation motifs (ITAMs) to which it binds using its tandem SH2 domains. Activated and autophosphorylated Syk then phosphorylates its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.

Specifications

• Antigen: SYK
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SYK
• Gene Alias: Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-syk
• Host Species: Mouse
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 6850
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunoprecipitation
• Clone: 8H5
• Formulation: HEPES with 0.01% BSA, 0.15M NaCl, 50% glycerol and 0.03% sodium azide
• Gene Accession No.: P43405
• Gene Symbols: SYK
• Immunogen: Synthetic peptide
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1