SOD3 Mouse anti-Human, Clone: 1H12, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen LFMA0121

Product Code. 10706221

Description

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.

A suggested positive control for this product is Bosc23 cells transfected with Myc-His-SOD3.

Specifications

• Antigen: SOD3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: P08294
• Gene Symbols: SOD3
• Immunogen: Purified, recombit, human superoxide dismutase 3 protein expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 1H12
• Gene: SOD3
• Gene Alias: SOD3, ALS, ALS1, Cu/Zn superoxide dismutase
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 6649
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid