anti-Superoxide Dismutase 1 Polyclonal, Thermo Scientific™

Superoxide Dismutase 1 Polyclonal Ab PA1-18276 from Thermo Scientific™ detects Superoxide Dismutase 1 in Hu samples, and is validated for IHC (Paraffin, Frozen) and WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-18274

SUPEROXIDE DISMUTASE 1

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11561942

Quantity Price
1 £ 285.0 / 100µL
Estimated Shipment date
from Supplier 11-01-2017
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Description and Specification

Specification

Antigen Superoxide Dismutase 1
Applications Western Blotting
Conjugate Unlabeled
Cross Reactivity Human
Format Serum
Formulation 100μL unpurified antibody in whole serum and no preservative
Gene Accession No. P00441
Gene Alias SOD1, ALS, ALS1, Cu/Zn superoxide dismutase, Homodimer, Indophenoloxidase A, IPOA
Gene Symbols SOD1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues E(24) S N G P V K V W G S I K(36) of human superoxide dismutase (SOD1).
Isotype IgG
Quantity 100μL
Species Reactivity Human
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 6647

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3) (1). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit (2). The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain (3). SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways (4). SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues E(24) S N G P V K V W G S I K(36) of human superoxide dismutase (SOD1).
Formulation: 100μL unpurified antibody in whole serum and no preservative
Synonyms: SOD1, ALS, ALS1, Cu/Zn superoxide dismutase, Homodimer, Indophenoloxidase A, IPOA
Uniprot Accession: P00441
Entrez GeneID: 6647
Gene Symbol: SOD1
PA1-18274 detects Superoxide Dismutase 1 from human samples. PA1-18274 has been successfully used in Western blot procedures. The PA1-18274 immunogen is a synthetic peptide corresponding to residues E(24) S N G P V K V W G S I K(36) of human superoxide dismutase (SOD1), conjugated to diphtheria toxoid. After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid freeze/thaw cycles. Reconstitute with 100 ul of distilled water.