Stat2 (pY690) Mouse anti-Human, Unlabeled, Clone: 7A/STAT2 (PY690), BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 558095

Product Code. 15809208

Description

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat2 is a 113kDa protein having approximately 40% homology with Stat1a. Stat2 interacts with Stat1 for the efficient activation of Stat1 in response to IFN-α, which is essential for normal transcriptional activity of the ISGF3 complex. Stat2 phosphorylation at the tyrosine 690 residue (Y690) after IFN-α activation can occur independently of Stat1, but the localization and nuclear stability of phosphorylated Stat2 is dependent on Stat1. The 7a/Stat2 monoclonal antibody recognizes the phosphorylated Y690 of human Stat2.

Host Species: Mouse
Clone: 7a
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human Stat2 Peptide

Western Blotting

Specifications

• Antigen: Stat2 (pY690)
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Phosphorylated Human Stat2 Peptide
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Western Blot
• Clone: 7A/STAT2 (PY690)
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.