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Stat 6 (pY641) Mouse anti-Human, Unlabeled, Clone: 18/P-STAT6, BD
Mouse Monoclonal Antibody
£242.93 - £443.49
Specifications
| Antigen | Stat 6 (pY641) |
|---|---|
| Clone | 18/P-STAT6 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15835979
|
BD Biosciences
611566 |
50 μg |
 £253.00 £242.93 / 1 set Save £10.07 3% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
15845979
|
BD Biosciences
611567 |
150 μg |
£462.00 £443.49 / 1 set Save £18.51 4% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development. It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). Stat6, a member of the signal transducers and activators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon,
intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors. The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity.
Host Species: Mouse
Clone: 18
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Phosphorylated Human Stat6 (pY641)
Formula Weight [Chemical]: 100kDa
Immunofluorescence, Intracellular Staining, Western Blotting
Specifications
| Stat 6 (pY641) | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a | |
| Affinity Purified |
| 18/P-STAT6 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human | |
| Phosphorylated Human Stat6 (pY641) | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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