Sphingosine Kinase 2 Polyclonal Antibody, Invitrogen™
Sphingosine Kinase 2 Antibody, PA1-12720, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: ELISA, Western Blot.
Brand: Invitrogen PA112720
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionSphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cellcell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to the C-terminal of Sphingosine Kinase 2.
Formulation: 10 Miniblots purified antibody in PBS and 0.08% sodium azide
Synonyms: C76851, MGC102297
Uniprot Accession: Q8CI19, Q9EQX6, Q9NRA1
Entrez GeneID: 54635, 56034, 79429
Gene Symbol: PDGFC
A suggested positive control for this product is active recombinant sphingosine kinase enzyme.
|Sphingosine Kinase 2|
|Q8CI19, Q9EQX6, Q9NRA1|
|Avoid Freeze/Thaw Cycles|
|10 Miniblots purified antibody in PBS and 0.08% sodium azide|
|Synthetic peptide corresponding to the C-terminal of Sphingosine Kinase 2.|
|54635, 56034, 79429|