anti-Sphingosine Kinase 2 Polyclonal, Thermo Scientific™

Sphingosine Kinase 2 Polyclonal Ab PA1-12720 from Thermo Scientific™ specifically detects Sphingosine Kinase 2 in Hu, Ms and Rt samples, and it is validated for ELISA and WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-12720

Sphingosine Kinase 2 Rabbit polyclonal antibody

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11586082

Quantity Price
1 £ 411.0 / 1 set
Estimated Shipment date
from Supplier 05-01-2017
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Description and Specification

Specification

Antigen Sphingosine Kinase 2
Applications Enzyme Linked Immunosorbent Assay
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Formulation 10 Miniblots purified antibody in PBS and 0.08% sodium azide
Gene Accession No. Q8CI19, Q9EQX6, Q9NRA1
Gene Alias C76851, MGC102297
Gene Symbols PDGFC
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the C-terminal of Sphingosine Kinase 2.
Isotype IgG
Quantity 10 Miniblots
Species Reactivity Human, Mouse, Rat
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 54635, 56034, 79429

Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cellcell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to the C-terminal of Sphingosine Kinase 2.
Formulation: 10 Miniblots purified antibody in PBS and 0.08% sodium azide
Synonyms: C76851, MGC102297
Uniprot Accession: Q8CI19, Q9EQX6, Q9NRA1
Entrez GeneID: 54635, 56034, 79429
Gene Symbol: PDGFC
A suggested positive control for this product is active recombinant sphingosine kinase enzyme.