SIAH1, E3 Ubiquitin Ligase Polyclonal Antibody, Invitrogen™

SIAH1, E3 Ubiquitin Ligase Antibody, PA1-12863, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-12863

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11540523

Quantity Price
1 £ 352.0 / 50µg
Estimated Shipment date
from Supplier 25-04-2017
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Description and Specification

Specification

Applications Western Blot
Gene ID (Entrez) 6477
Formulation 50μg purified antibody in PBS and 0.08% sodium azide
Storage Requirements Avoid Freeze/Thaw Cycles
Antigen SIAH1, E3 Ubiquitin Ligase
Cross Reactivity Human
Isotype IgG
Immunogen Synthetic peptide corresponding to human SIAH-1.
Primary or Secondary Primary
Format Purified
Gene Accession No. Q8IUQ4
Conjugate Unlabeled
Host Species Rabbit
Species Reactivity Human
Monoclonal or Polyclonal Polyclonal
Quantity 50μg
Gene Symbols SIAH1
Gene Alias HUMSIAH, Siah-1, Siah-1a, hSIAH1

Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human SIAH-1.
Formulation: 50μg purified antibody in PBS and 0.08% sodium azide
Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
Uniprot Accession: Q8IUQ4
Entrez GeneID: 6477
Gene Symbol: SIAH1
A suggested positive control for this product is human brain lysate.