anti-SIAH1, E3 Ubiquitin Ligase Polyclonal, Thermo Scientific™

SIAH1, E3 Ubiquitin Ligase Polyclonal Ab PA1-12861 from Thermo Scientific™ specifically detects SIAH1, E3 Ubiquitin Ligase in Hu samples, and it is validated for WB

Brand: Invitrogen

Manufacturer Part Number: PA1-12863


UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg

Product Code. 11540523

Quantity Price
1 £352.00 / 50µg
Estimated Shipment date
from Supplier 17-11-2016
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Description and Specification


Antigen SIAH1, E3 Ubiquitin Ligase
Applications Western Blotting
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation 50μg purified antibody in PBS and 0.08% sodium azide
Gene Accession No. Q8IUQ4
Gene Alias HUMSIAH, Siah-1, Siah-1a, hSIAH1
Gene Symbols SIAH1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to human SIAH-1.
Isotype IgG
Quantity 50μg
Species Reactivity Human
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 6477

Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human SIAH-1.
Formulation: 50μg purified antibody in PBS and 0.08% sodium azide
Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
Uniprot Accession: Q8IUQ4
Entrez GeneID: 6477
Gene Symbol: SIAH1
A suggested positive control for this product is human brain lysate.