SIAH1, E3 Ubiquitin Ligase Polyclonal Antibody, Invitrogen™
SIAH1, E3 Ubiquitin Ligase Antibody, PA1-12863, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.
Brand: Invitrogen PA112863
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionSeven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
Host Species: Rabbit
Cross Reactivity: Human
Immunogen: Synthetic peptide corresponding to human SIAH-1.
Formulation: 50μg purified antibody in PBS and 0.08% sodium azide
Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
Uniprot Accession: Q8IUQ4
Entrez GeneID: 6477
Gene Symbol: SIAH1
A suggested positive control for this product is human brain lysate.
|SIAH1, E3 Ubiquitin Ligase|
|HUMSIAH, Siah-1, Siah-1a, hSIAH1|
|Avoid Freeze/Thaw Cycles|
|50μg purified antibody in PBS and 0.08% sodium azide|
|Synthetic peptide corresponding to human SIAH-1.|