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SIAH1, E3 Ubiquitin Ligase Polyclonal Antibody, Invitrogen™

SIAH1, E3 Ubiquitin Ligase Antibody, PA1-12861, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.

Brand:  Invitrogen PA112861

UNSPSC : 12352203

Code : LD

Additional Details : Weight : 0.01000kg

Product Code. 11520523

  • £273.00 / 100µg


Estimated Shipment
25-08-2017
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Specifications

Description

Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human SIAH-1.
Formulation: 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
Uniprot Accession: Q8IUQ4
Entrez GeneID: 6477
Gene Symbol: SIAH1
A suggested positive control for this product is human brain lysate.
Description & Specifications

Specifications

SIAH1, E3 Ubiquitin Ligase
Unlabeled
Q8IUQ4
HUMSIAH, Siah-1, Siah-1a, hSIAH1
Rabbit
IgG
Avoid Freeze/Thaw Cycles
Polyclonal
Human
Western Blot
100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Purified
SIAH1
Synthetic peptide corresponding to human SIAH-1.
100μg
Primary
6477