anti-SIAH1, E3 Ubiquitin Ligase Polyclonal, Thermo Scientific™

SIAH1, E3 Ubiquitin Ligase Polyclonal Ab PA1-12861 from Thermo Scientific™ specifically detects SIAH1, E3 Ubiquitin Ligase in Hu samples, and it is validated for WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-12861

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11520523

Quantity Price
1 £ 273.0 / 100µg
Estimated Shipment date
from Supplier 23-03-2017
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Description and Specification

Specification

Gene ID (Entrez) 6477
Formulation 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Cross Reactivity Human
Antigen SIAH1, E3 Ubiquitin Ligase
Storage Requirements Avoid Freeze/Thaw Cycles
Isotype IgG
Immunogen Synthetic peptide corresponding to human SIAH-1.
Primary or Secondary Primary
Format Purified
Gene Accession No. Q8IUQ4
Species Reactivity Human
Conjugate Unlabeled
Host Species Rabbit
Quantity 100μg
Monoclonal or Polyclonal Polyclonal
Gene Symbols SIAH1
Applications Western Blotting
Gene Alias HUMSIAH, Siah-1, Siah-1a, hSIAH1

Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human SIAH-1.
Formulation: 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
Uniprot Accession: Q8IUQ4
Entrez GeneID: 6477
Gene Symbol: SIAH1
A suggested positive control for this product is human brain lysate.