Invitrogen™ SHOX Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA537220

Product Code. 15584301

Description

This antibody detects endogenous protein at a molecular weight of 29 kDa. Purity is >95% by SDS-PAGE.

Homeodomain proteins (HP) are transcriptional regulators that coordinate the expression of genes involved in development, differentiation and cellular transformation. HPs are characterized by a conserved domain of 60 amino acid residues that recognize and bind a site in the regulatory region of the target gene. SHOX, a member of the bicoid subfamily of the paired homeobox family, controls fundamental aspects of growth and development and undergoes splicing resulting in two isoforms, SHOXA and SHOXB. SHOXA is expressed in skeletal muscle, placental, pancreas, heart and bone marrow fibroblast and, to a lesser extent, in kidney and lung. SHOXB is highly expressed in osteogenic cells, but not expressed in brain, kidney, liver or lung. Defects in the gene SHOXX cause Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD).

Specifications

• Antigen: SHOX
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHOX
• Gene Alias: GCFX; growth control factor, X-linked; PHOG; Pseudoautosomal homeobox-containing osteogenic protein; short stature homeobox; short stature homeobox protein; Short stature homeobox-containing protein; SHOX; SHOXY; SS
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6473
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O15266
• Gene Symbols: SHOX
• Immunogen: A synthetic peptide corresponding to residues in human SHOX.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG