Serotonin Receptor 5-HT2BR Mouse, Unlabeled, Clone: A72-1, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 556334

Product Code. 15858658

Description

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor, plays an important role in regulating diverse biological processes in the central and peripheral nervous systems, the cardiovascular system and the gastrointestinal systems. The different functions of serotonin are thought to be mediated through specific receptors. Physiological, biochemical, and pharmacological studies have defined at least fourteen serotonin receptors. The fourteen receptors are grouped in seven subtypes according to operational, structural, and transductional properties. The 5-HT2 receptors (5 -HT[2A]R, 5-HT[2B]R, an d 5-HT[2C]R) may be considered as prototypes for the study of serotonin receptors . Their functions are mediated by the second messenger inositol polyphosphate in a G-protein coupled pathway. They are expressed in diverse tissues including brain, vascular smooth muscles and platelets. The 5-HT[2A]R-mRNAs have been found in only a few areas of the brain, including the frontal cortex, piriform cortex, ventro-caudal part of CA3, motor cranial nerve nuclei in the brainstem, and the ventral horn of the spinal cord. The 5-HT[2C]R mRNA has been found at high levels in many parts of the brain including retrosplenial piriform and
entorhinal cortex, anterior olfactory nucleus, substantia nigra pars compacta, several brainstem nuclei and the whole grey matter of the spinal cord. The 5-HT[2B]R was cloned in stomach fundus, where it is abundantly expressed.

Host Species: Mouse
Clone: A72-1
Isotype: IgG1 κ
Species Reactivity: Rat
Immunogen: Human 5HT[2B]R (aa. 1-58) fusion protein

Immunohistochemistry (Frozen), Western Blotting

Specifications

• Antigen: Serotonin Receptor 5-HT2BR
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human 5HT[2B]R (aa. 1-58) fusion protein
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human, Rat
• Isotype: IgG1 κ

• Applications: Western Blot
• Clone: A72-1
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.