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S6 (pS235/pS236) Mouse, Alexa Fluor 647, Clone: N7-548, BD

Product Code. 12840480
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Product Code. 12840480 Supplier BD Biosciences Supplier No. 560435

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Description

Mouse Monoclonal Antibody

Ribosomal protein S6 (∽29kDa calculated and ∽32kDa observed molecular weights) is a component of the 40S ribosomal subunit and belongs to the S6E family of ribosomal proteins. The S6 ribosomal protein plays a role in regulating the translation of RNAs and thus controlling the growth and proliferation of cells. S6 ribosomal protein phosphorylation, especially at multiple C-terminal serine residues S235, S236, S240, and S244, activates S6. The activated S6 ribosomal protein in turn upregulates the ribosomal translation of RNA species coding for other ribosomal proteins, peptide elongation factors and other proteins involved in cell cycle entry and progression. These phosphorylations are mediated by various kinases (e.g., p70S6K and PKCD) activated through cellular responses to growth factors, cytokines, tumor promoting agents, and mitogens. The S6 ribosomal protein can be dephosphorylated in growth-arrested cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen S6 (pS235/pS236)
Applications Flow Cytometry
Classification Monoclonal
Clone N7-548
Conjugate Alexa Fluor 647
Description 40S ribosomal protein S6; Phosphoprotein NP33; RPS6; RS6
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human ribosomal protein S6 Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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