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Description
The O28-835 monoclonal antibody recognizes ROR-gamma ( RORγ) and its isoform, RORγt. RORγ(∽58 kDa calculated molecular weight) is a DNA-binding transcription factor that belongs to the ROR/RZR orphan nuclear receptor family. It is expressed in different tissues including skeletal muscle, kidney, liver and adipose tissues. RORγt ( ∽56 kDa calculated molecular weight ) is a RORγisoform that is expressed exclusively by lymphoid cells. It is expressed by various lymphoid cell types including CD4+CD8+ thymocytes, peripheral CD4+ Th17 and CD8+ Tc17 cells and lymphoid tissue inducer (Lti) cells. RORγt plays essential roles in thymopoiesis, T cell homeostasis, differentiation of effector T lymphocytes and the development of secondary lymphoid tissues including lymph nodes and Peyer’s patches.
Specifications
| RORgt | |
| Monoclonal | |
| 0.5mg/mL | |
| Rorc; Rorg; RORgamma; Rorγ; RORgt; RORgammat; RORγt; TOR; Thor; Nr1f3; ROR | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgG2b κ |
| Western Blot | |
| O28-835 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Human RORγt Recombinant Protein | |
| 0.1 mg | |
| Primary | |
| Store undiluted at 4°C |
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