ROC1 Polyclonal Antibody, Invitrogen™

ROC1 Antibody, PA5-16282, from Invitrogen™. Species Reactivity: Human, Mouse; Applications: Immunoprecipitation, Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA5-16282

UNSPSC: 12352203

Code: A0

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11375743

Quantity Price
1 £ 315.0 / 500µL
Estimated Shipment date
from Supplier 18-04-2017
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Description and Specification

Specification

Formulation 500μL purified antibody (1mg/mL) in PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Applications Immunoprecipitation
Applications Western Blot
Antigen ROC1
Cross Reactivity Human
Cross Reactivity Mouse
Storage Requirements Store at 4° C
Immunogen A peptide corresponding to amino acid residue 97-108 (CPLDNREWEFQKYGH) from C-terminus of the human ROC1
Isotype IgG
Primary or Secondary Primary
Format Purified
Gene Accession No. P62877, P62878
Regulatory Status RUO
Conjugate Unlabeled
Host Species Rabbit
Species Reactivity Human, Mouse
Quantity 500μL
Monoclonal or Polyclonal Polyclonal
Gene Symbols RBX1
Gene Alias RING box protein 1, RING finger protein 75, RING-box protein 1, ZYP protein, regulator of cullins 1
Gene ID (Entrez) 56438, 9978

ROC1 and ROC2 are the two highly conserved RING finger proteins that are homologous to APC11, a subunit of the anaphase-promoting complex(APC). ROC1 and ROC2 commonly interact with all cullins while APC11 specifically interacts with APC2, a cullin-related APC subunit. ROC1 and APC11 immunocomplexes can catalyze isopeptide ligations to form polyubiquitin chains in an E1- and E2-dependent manner. ROC1 is thought to play a unique role in the ubiquitination reaction by heterodimerizing with cullin1 to catalyze ubiquitin polymerization.
Host Species: Rabbit
Cross Reactivity: Human, Mouse
Isotype: IgG
Immunogen: A peptide corresponding to amino acid residue 97-108 (CPLDNREWEFQKYGH) from C-terminus of the human ROC1
Formulation: 500μL purified antibody (1mg/mL) in PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Synonyms: RING box protein 1, RING finger protein 75, RING-box protein 1, ZYP protein, regulator of cullins 1
Uniprot Accession: P62877, P62878
Entrez GeneID: 56438, 9978
Gene Symbol: RBX1
PA5-16282 targets ROC1 in IP and WB applications and shows reactivity with Human and mouse samples. The PA5-16282 immunogen is a peptide corresponding to amino acid residue 97-108 (CPLDNREWEFQKYGH) from C-terminus of the human ROC1.