Invitrogen™ Reg3D Monoclonal Antibody (518818)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA524226

Product Code. 15593912

Description

In direct ELISAs, no cross-reactivity with recombinant human (rh) Reg1A, 1B, recombinant mouse (rm) Reg1, 2, 3A, 3B, 3G, 4, or recombinant rat Reg3 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

The Reg3D gene encodes the regenerating islet-derived protein 3 delta, a member of the Reg protein family, which is involved in tissue regeneration, particularly within the pancreas. Reg3D proteins are known for their significant roles in the protection and regeneration of pancreatic islet cells, aiding in the maintenance of glucose homeostasis during pancreatic stress or damage. They possess bactericidal properties, contributing to the innate immunity of the gastrointestinal tract by providing a defensive mechanism against microbial invasion. The expression of Reg3D is upregulated in response to intestinal bacterial infections, supporting mucosal defenses and preventing pathogen colonization. While closely related to other Reg family members, Reg3D's specific functions and regulatory mechanisms continue to be elucidated, with ongoing research exploring its potential therapeutic applications in conditions such as diabetes and pancreatitis. Understanding the role of Reg3D in pancreatic and gastrointestinal health is crucial for developing strategies to enhance tissue repair and immune functions in related diseases.

Specifications

• Antigen: Reg3D
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: 0
• Gene Symbols: Reg3d
• Immunogen: E. coli-derived recombinant mouse Reg3D Glu27-Gly175.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Clone: 518818
• Conjugate: Unconjugated
• Gene: Reg3d
• Gene Alias: INGAP; Ingaprp; islet neogenesis associated protein-related protein; Reg III delta; Reg3d; regenerating islet-derived 3 delta
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 30053
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized