Invitrogen™ PLK4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA529373

Product Code. 13463547

Description

Recommended positive controls: PLK4-transfected 293T. Predicted reactivity: Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells. The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.

Specifications

• Antigen: PLK4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLK4
• Gene Alias: 1700028H20; AI385771; MCCRP2; PLK4; PLK-4; polo like kinase 4; polo-like kinase 4; SAK; serine/threonine kinase 18; serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak; Snk akin kinase; Stk18
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10733
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.19 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O00444
• Gene Symbols: PLK4
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human PLK4. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG