PIP5Kγ Mouse, Unlabeled, Clone: 12, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 611148

Product Code. 15855819

Description

Phosphoinositide turnover is a well established mechanism of intracellular signal transduction. Sequential phosphorylation of phosphatidylinositol (PtdIns) results in PtdIns(4)P (PIP) and PtdIns(4,5)P2 (PIP2). Phospholipase C (PLC) hydrolyzes PIP2 to inositol (1,4,5)P3 (IP3) which stimulates release of intracellular Ca²⁺. PIP2 is generated by phosphorylation of PtdIns 5-kinases (PI5-K). These enzymes are divided into two types (I and II) based on their size and sensitivity to certain compounds. Three mammalian PI5-Ks, PI5-Kα, β, and γ of type I have been identified and a type II PIP5kα. Although the PI4-Ks are abundantly distributed throughout the cell, activity is found primarily in association with membranous structures. Members of this family contain a lipid kinase unique domain and a C-terminal catalytic domain.

Host Species: Mouse
Clone: 12
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse PIP5Kγ aa. 479-580
Formula Weight [Chemical]: 87-90kDa

Immunofluorescence, Western Blotting

Specifications

• Antigen: PIP5Kγ
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Mouse PIP5Kγ aa. 479-580
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Mouse, Rat
• Isotype: IgG1

• Applications: Western Blot
• Clone: 12
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.