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PI4-Kinase β Mouse, Unlabeled, Clone: 7, BD
Mouse Monoclonal Antibody
£185.50 - £307.25
Specifications
| Antigen | PI4-Kinase β |
|---|---|
| Clone | 7 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15886029
|
BD Biosciences
611816 |
50 μg |
 £193.00 £185.50 / 1 set Save £7.50 3% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
15896029
|
BD Biosciences
611817 |
150 μg |
£311.00 £307.25 / 1 set Save £3.75 1% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Phosphoinositide turnover is a well established mechanism of intracellular signal transduction. Sequential phosphorylation of phosphatidylinositol (PtdIns) results inPtdIns-4-phosphate (PIP) and PtdIns-4,5-bisphosphate (PIP2). Phospholipase C (PLC)hydrolyzes PIP2 to inositol-1,4,5-trisphosphate (IP3) which stimulates release of intracellular Ca2+. PIP is generated by phosphorylation of PtdIns at the D4 position of the inositol ring. This event is mediated by the PtdIns 4-kinases (PI4-K). These enzymes are divided into two types (II and III) based on their size and sensitivity to certain compounds. Although the PI4-Ks are abundantly distributed throughout the cell, activity is found primarily in association with membranous structures. Members of this family contain a lipid kinase unique domain and a C-terminal catalytic domain. Two mammalian PI4-Ks, PI4-Kα and PI4-Kβ, have been identified. PI4-Kβ is homologous to the yeast PI4-K, PIK1. Based on its size and sensitivity to wortmanin (a PI3-K inhibitor), PI4-Kβ is classified as a type III enzyme. Although it is found in the cytosol and in association with the Golgi, the specific function of PI4-Kβ is yet to be determined.
Host Species: Mouse
Clone: 7
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human PI4Kβ aa. 411-626
Immunofluorescence, Western Blotting
Specifications
| PI4-Kinase β | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a | |
| Affinity Purified |
| 7 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Human, Mouse, Rat | |
| Human PI4Kβ aa. 411-626 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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