missing translation for 'onlineSavingsMsg'
Learn More
Learn More
PI3-Kinase p110α Mouse, Unlabeled, Clone: 19, BD
Mouse Monoclonal Antibody
£237.00 - £284.36
Specifications
| Antigen | PI3-Kinase p110α |
|---|---|
| Clone | 19 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15855919
|
BD Biosciences
611398 |
50 μg | |||||||
|
15865919
|
BD Biosciences
611399 |
150 μg |
 £297.00 £284.36 / 1 set Save £12.64 4% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Phosphatidylinositol 3 (PI3) -kinase participates in insulin-stimulated glucose uptake, PDGF-induced membrane ruffling, and G-protein receptor signaling. It exists as a heterodimer of 85kDa (p85) and 110kDa (p110) subunits. The p85 subunit associates with and serves as a substrate for activated growth factor receptor tyrosine kinases. p85 regulates the p110 catalytic subunit by acting as the link between PI3-kinase and the ligand-activated receptor. Four isoforms of p110 have been identified (α, β, γ, and δ). The p110α isoform contains an N-terminal region involved in p85 binding and a C-terminal kinase domain. p85/p110α-type PI kinase phosphorylates the D-3 and D-4
position of the inositol ring of PI, thereby producing PtdIns(3)P, PtdIns(3,4)P[2], PtdIns(3,4,5)P[3], PtdIns(4)P, and PtdIns(4,5) P[2]. During induction of chemotaxis by the chemokine SDF-1α, PI3-kinase regulates adhesion and ERM protein redistribution in the lymphocyte plasma membrane. In addition, PI3-kinases activate other signaling molecules, such as p70 S6 kinase and Akt/protein kinase B. Thus, p85/p110α-type PI kinase is a ubiquitously expressed kinase that is involved in a variety of cell signaling cascades.
Host Species: Mouse
Clone: 19
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PI3-Kinase p110α aa. 101-300
Formula Weight [Chemical]: 110kDa
Immunofluorescence, Western Blotting
Specifications
| PI3-Kinase p110α | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 19 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Rat | |
| Human PI3-Kinase p110α aa. 101-300 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
Spot an opportunity for improvement?Share a Content Correction
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title