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Phospho-Vinculin (Tyr821) Polyclonal Antibody, Invitrogen™

Product Code. 15505471
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Quantity:
100 μg
Unit Size:
100µg
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15505471 100 μg 100µg
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Product Code. 15505471 Supplier Invitrogen Supplier No. PA538546

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Description

Rabbit Polyclonal Antibody

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Vinculin (Tyr821)
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene VCL
Gene Accession No. P18206, Q64727, P85972
Gene Alias Vinculin
Gene Symbols VCL
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human Vinculin around the phosphorylation site of Tyr821 (S-G-YP-R-I)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22330, 305679, 7414
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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