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Invitrogen™ Phospho-PKC alpha/beta-2 (Thr638, Thr641) Polyclonal Antibody
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Product Code. 11393152
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Quantity:
100 μL
Unit Size:
100µL
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11393152 100 μL 100µL
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Product Code. 11393152 Supplier Invitrogen™ Supplier No. PA517904

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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
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Specifications

Antigen Phospho-PKC alpha/beta-2 (Thr638, Thr641)
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene PRKCB
Gene Accession No. P05696, P05771, P20444, P68403, P68404
Gene Alias A130082F03Rik; AAG6; aging-associated gene 6; AI875142; PKCA; PKC-A; PKC-alpha; Pkcb; PKC-B; PKC-beta; PRKACA; PRKC Pan; PRKCA; PRKCB; PRKCB1; Prkcb2; protein kinase C alpha; protein kinase C alpha type; protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C, alpha; protein kinase C, beta; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase c-alpha
Gene Symbols Prkca, PRKCB
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding pThr638 of human PKC alpha.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18750, 18751, 24680, 25023, 5579
Target Species Hamster, Human, Mouse, Monkey, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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