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Phospho-PI3K p85/p55 (Tyr467, Tyr199) Polyclonal Antibody, Invitrogen™

Product Code. 15487724
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Quantity:
100 μg
Unit Size:
1µg
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15487724 100 μg 1µg
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Product Code. 15487724 Supplier Invitrogen Supplier No. PA538903

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Description

Rabbit Polyclonal Antibody

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110kDa catalytic subunit and a regulatory subunit of either 85, 55, or 50kDa. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1.
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Specifications

Antigen Phospho-PI3K p85/p55 (Tyr467, Tyr199)
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PIK3R3
Gene Accession No. P27986, Q92569, P26450, Q64143, Q63787, Q63789
Gene Alias Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-al, RP4-533D7.2, p55, p55-GAMMA, 100% homology to SWISS-PROT Q92569, PI3-kinase regulatory subunit gamma, PI3-kinase subunit p55-gamma, PI3K regulatory subunit gamma, p55PIK, phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, phosphatidylinositol 3-kinase regulatory subunit gamma, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma), phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma), phosphoinositide-3-kinase, regulatory subunit, polypeptide 3
Gene Symbols PIK3R1, PIK3R3
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human PI3-kinase p85-subunit alpha/gamma around the phosphorylation site of Tyr467/199 (R-L-YP-E-E)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18708, 18710, 25513, 5295, 60664, 8503
Target Species Human, Mouse, Non-human Primate, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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