PGC1 alpha Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538022

Product Code. 15564951

Description

A recommended positive control is human heart tissue lysate. At least three isoforms of PPARGC1A are known to exist; this antibody will detect all three isoforms.

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it′s interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Specifications

• Antigen: PGC1 alpha
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PPARGC1A
• Gene Alias: PPARGC1A, LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, LEM6, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6, PGC-1-alpha
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10891, 19017, 83516
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9UBK2, O70343, Q9QYK2
• Gene Symbols: PPARGC1A
• Immunogen: 17 amino acid peptide near the amino terminus of human PPARGC1A
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG