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p53 (pS37) Mouse anti-Human, Alexa Fluor 488, Clone: J159-641.79, BD

Product Code. 15800079
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Product Code. 15800079 Supplier BD Biosciences Supplier No. 560282

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Description

Mouse Monoclonal Antibody

The p53 protein is critical to regulation of normal cell growth and is a suppressor of tumor cell proliferation. Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression. Mutations and/or allelic loss of the p53 gene are associated with a wide variety of human tumors. Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53 also binds to DNA in a sequence-specific manner via recognition of a 20-bp consensus-binding site. This interaction stimulates the expression of genes downstream
of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase, which primarily prevent cell proliferation. MDM2 mediates feedback inhibition of p53, which is prevented by phosphorylations of p53 amino-terminal serines and threonines. Upon exposure to DNA damage-inducing agents, ATR and DNA-PK (ataxia telangiectasia- and Rad3-related and DNA-dependent protein kinases, respectively) phosphorylate p53 at serine 37 (S37). This phosphorylation disrupts the binding of MDM2 to p53, allowing the cell's stress responses to proceed.

Host Species: Mouse
Clone: J159-641.79
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human p53 Peptide

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen p53 (pS37)
Applications Flow Cytometry
Classification Monoclonal
Clone J159-641.79
Conjugate Alexa Fluor 488
Description TP53
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human p53 Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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