p53 Mouse anti-Human, Unlabeled, Clone: PAB 1801, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15847598	BD Biosciences 554169	0.1 mg

Description

The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers. Missense mutations occur in tumors of the colon, lung, breast, ovary, bladder and several other organs. The mutant p53 is over-expressed in a variety of transformed cells and it forms specific complexes with several viral oncogenes including SV40 large T, E1B from adenovirus and E6 from human papilloma virus. Recent data suggest that wild type p53 plays a role as a checkpoint protein for DNA damage during the S-phase of the cell cycle. However, it is still unclear whether point mutated forms of p53 are simple null mutants and/or dominant negatively acting proteins. p53 migrates at a reduced molecular weight of 53kDa. Clone PAb 1801 recognizes an epitope between amino acids 32-79 in the N-terminal domain of human wild type and mutant p53 antibody. It does not cross-react with p53 from other species. A truncated recombinant human p53 fusion protein was used as immunogen.

Host Species: Mouse
Clone: PAb 1801
Isotype: IgG1
Species Reactivity: Human
Immunogen: Recombinant fusion protein
Formula Weight [Chemical]: 53kDa

Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

Specifications

• Antigen: p53
• Concentration: 0.5mg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Immunogen: Recombinant fusion protein
• Primary or Secondary: Primary

• Clone: PAB 1801
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1
• Purification Method: Affinity Purified

For Research Use Only.