P-glycoprotein Mouse anti-Human, Unlabeled, Clone: 17F9, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 557001

Product Code. 15868808

Description

Reacts with a 170-180kDa transmembrane glycoprotein (P-glycoprotein), a product of the multidrug resistance-1 (MDR1) gene. This glycoprotein is expressed on MDR positive cells and has been reported to be expressed on many normal tissues, such as adrenal glands and endothelium, in the brain and skin. P-glycoprotein is known to impart drug resistance to cells by pumping many anti-cancer drugs out of the cytoplasm. 17F9 antibody binds to the surface of the viable, unfixed MDR+ cell line, PMG-Y (please inquire), and is able to partially block the binding of UIC2 antibody (another MDR-specific monoclonal antibody). Immunoprecipitation application is reported, but not routinely tested in house.

Host Species: Mouse
Clone: 17F9
Isotype: IgG2b, κ
Cross Reactivity: Human

Flow Cytometry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: P-glycoprotein
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: CD243; ABCB1; ABC20; CLCS; GP170; MDR1; P-GP; PGY1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: 17F9
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human MDR1 Transfected Cell Line
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG2b κ

For Research Use Only.