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NOXA Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA118332
This item is not returnable.
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Description
Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
Specifications
| NOXA | |
| Polyclonal | |
| Unconjugated | |
| PMAIP1 | |
| adult T cell leukemia-derived PMA-responsive; APR; Immediate-early-response protein APR; Noxa; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Pmaip1; Protein Noxa | |
| Rabbit | |
| 100 μL | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
| Western Blot | |
| Conc. Not Determined | |
| whole serum with no preservative | |
| Q9JM54 | |
| PMAIP1 | |
| Synthetic peptide corresponding to residues C(75) A Q L R R I G D K V N L R Q K(90) of mouse Noxa. | |
| RUO | |
| 58801 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Lyophilized |