Invitrogen™ Nogo-A/B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA141220

Product Code. 11558171

Description

Suggested positive control: human, mouse or rat brain.

Nogo-B is a novel myelin-associated, intermediate-length splice variant of Nogo belonging to the reticulon family. It is a multidomain neurite growth inhibitory protein containing several discrete regions with growth inhibitory functions and is a component of the CNS myelin that prevents axonal regeneration in the adult vertebrate CNS. Nogo-B along with NGBR mediated chemotaxis in HUVECs and induced tube formation in 3-dimensional cultures. It is mostly found in intact blood vessels, smooth muscle cells, and endothelial cell, with its N terminus oriented extracellularly and is a regulator of vascular homeostasis and remodeling. It plays an important role in sporadic and familial amyotrophic lateral sclerosis.

Specifications

• Antigen: Nogo-A/B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RTN4
• Gene Alias: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; Foocen; glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Human NogoA; KIAA0886; MGC116054; mKIAA0886; mKIAA4153; My043; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NgA; NI220/250; NI-220/250; NI-250; NOGO; nogo protein; Nogo-A; Nogo-B; NOGOC; Nogo-C; NSP; NSP-CL; r; rat N; rat NogoA; reticulon 4; reticulon 5; reticulon-4; Reticulon-5; Rtn4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; RTN-x; SP1507; Vp20
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100170399, 100338467, 57142, 68585, 83765
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q99P72, Q9JK11, Q9NQC3
• Gene Symbols: RTN4
• Immunogen: A synthetic peptide to an internal portion of human Nogo A (between amino acids 1-50).
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Sheep, Rabbit, Rat
• Product Type: Antibody
• Isotype: IgG