NKp46 Mouse anti-Human, APC, Clone: 9E2/NKP46, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 558051

Product Code. 15859178

Description

NKp46, a major cytoxicity receptor of NK cells, is a type I membrane glycoprotein (46kDa) is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3ζ and FcεRIγ adaptor proteins. NKp46 along with NKp30 and NKp44 are referred to as natural cytoxicity receptors (NCR) and play a very important role in killing virus-infected, tumor cells and MHC-class I-unprotected cells. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: 9E2/Nkp46
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: NKp46
• Classification: Monoclonal
• Conjugate: APC
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 9E2/NKP46
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human NKp46 Recombinant Protein
• Quantity: 100 Tests
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

For Research Use Only.