anti-Netrin 1 Polyclonal, Thermo Scientific™

Netrin 1 Polyclonal Ab PA1-12869 from Thermo Scientific™ specifically detects Netrin 1 in Bv, Feline, Hu, Ms, Nhp and Rt samples, and it is validated for WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-12869

NETRIN 1

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11500533

Quantity Price
1 £ 355.0 / 100µg
Estimated Shipment date
from Supplier 15-02-2017
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Description and Specification

Specification

Formulation 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Cross Reactivity Bovine
Cross Reactivity Feline
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Non-human primate
Cross Reactivity Rat
Antigen Netrin 1
Storage Requirements Avoid Freeze/Thaw Cycles
Immunogen Synthetic peptide corresponding to human Netrin 1.
Isotype IgG
Primary or Secondary Primary
Format Purified
Gene Accession No. O09118, O95631, Q924Z9
Host Species Rabbit
Conjugate Unlabeled
Species Reactivity Bovine, Feline, Human, Mouse, Non-human primate, Rat
Gene Alias NTN1L
Gene Symbols NTN1
Applications Western Blotting
Quantity 100μg
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 101082606, 114523, 18208, 522767, 9423

Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Host Species: Rabbit
Cross Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human Netrin 1.
Formulation: 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: NTN1L
Uniprot Accession: O09118, O95631, Q924Z9
Entrez GeneID: 101082606, 114523, 18208, 522767, 9423
Gene Symbol: NTN1
A suggested positive control for this product is MDCKII cell lysate.