Netrin 1 Polyclonal Antibody, Invitrogen™
Netrin 1 Antibody, PA1-12869, from Invitrogen™. Species Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat; Applications: Western Blot.
Brand: Invitrogen PA112869
UNSPSC : 12352203
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionNetrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Host Species: Rabbit
Cross Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat
Immunogen: Synthetic peptide corresponding to human Netrin 1.
Formulation: 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Uniprot Accession: O09118, O95631, Q924Z9
Entrez GeneID: 101082606, 114523, 18208, 522767, 9423
Gene Symbol: NTN1
A suggested positive control for this product is MDCKII cell lysate.
|O09118, O95631, Q924Z9|
|Avoid Freeze/Thaw Cycles|
|100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide|
|Synthetic peptide corresponding to human Netrin 1.|
|101082606, 114523, 18208, 522767, 9423|