Netrin 1 Polyclonal Antibody, Invitrogen™

Netrin 1 Antibody, PA1-12869, from Invitrogen™. Species Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat; Applications: Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-12869

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11500533

Quantity Price
1 £ 355.0 / 100µg
Estimated Shipment date
from Supplier 25-05-2017
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Description and Specification

Specification

Antigen Netrin 1
Applications Western Blot
Conjugate Unlabeled
Format Purified
Formulation 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Gene Accession No. O09118, O95631, Q924Z9
Gene Alias NTN1L
Gene Symbols NTN1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to human Netrin 1.
Isotype IgG
Quantity 100μg
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 101082606, 114523, 18208, 522767, 9423
Target Species Bovine
Target Species Feline
Target Species Human
Target Species Murine
Target Species Non-human Primate
Target Species Rat

Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Host Species: Rabbit
Cross Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human Netrin 1.
Formulation: 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: NTN1L
Uniprot Accession: O09118, O95631, Q924Z9
Entrez GeneID: 101082606, 114523, 18208, 522767, 9423
Gene Symbol: NTN1
A suggested positive control for this product is MDCKII cell lysate.