SCN1A Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA534187

Product Code. 15325191

Description

BLAST analysis of the peptide immunogen showed 100% homology with human protein SCN2A and 94% homology with SCN3A.

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Specifications

• Antigen: SCN1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Scn1a
• Gene Alias: 3-Feb; B230332M13; BFIC3; BFIS3; BFNIS; brain III voltage-gated sodium channel; Brain Type I; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2; CERIII; CIAT; CIN5; CMD1E; CMPD2; CMS16; CTC-264K15.6; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFS+2; GEFSP2; GEFSP7; HB1; HB2; HBA; HBBD; HBSC I; HBSC II; HBSCI; HBSCII; HH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; KIAA1356; LQT3; MED; Na(v)1.2; Na(V)1.4; NAC1; NAC1A; NAC2; NAC3; NaCh6; NaN; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.6; Nav1.7; Nav1.8; NAV1.9; NENA; NE-NA; Neuroendocrine sodium channel; peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; peripheral sodium channel 1; PFHB1; PN1; PN3; PN4; PN5; RBI; SCN1; SCN10A; SCN11A; SCN12A; Scn1a; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; SCN9A; Sensory neuron sodium channel 2; SFNP; skeletal muscle sodium channel alpha subunit;
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100052059, 100145897, 100752032, 106506270, 20265, 478775, 6323, 771555, 81574
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: A2APX8, P04774, P35498
• Gene Symbols: Scn1a
• Immunogen: Synthetic 16 amino acid peptide from N-terminus of human SCN1A / Nav1.1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Bat, X. laevis, Canine, Chicken, Equine, Hamster, Mouse, Mouse, Porcine, Porcine, Rat
• Product Type: Antibody
• Isotype: IgG