Nanog Mouse anti-Mouse, Alexa Fluor 488, Clone: M55-312, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 560278

Product Code. 15860069

Description

The M55-312 monoclonal antibody reacts with mouse Nanog (named for Tir Na Nog, the land of the ever-young of Celtic mythology), which is a homeobox transcription factor required for the maintenance of the undifferentiated state of pluripotent stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF (Leukemia Inhibitory Factor) and BMP (Bone Morphogenic Protein). When Nanog expression is down-regulated, cell differentiation can proceed. Proteins that regulate Nanog expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53.

Specifications

• Antigen: Nanog
• Classification: Monoclonal
• Conjugate: Alexa Fluor 488
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: M55-312
• Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
• Immunogen: Mouse Nanog Recombinant Protein
• Quantity: 50 Tests
• Research Discipline: Cell Biology
• Target Species: Mouse
• Isotype: IgG1 κ