MSH2 Mouse anti-Human, Clone: 25D12, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA512224

Product Code. 11394593

Description

MA5-12224 targets MSH2 (Mismatch Repair Protein 2) in IHC (P) applications and shows reactivity with Human samples. The MA5-12224 immunogen is recombit human MSH2 protein.

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.

Specifications

• Antigen: MSH2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MSH2
• Gene Alias: DNA mismatch repair protein Msh2,hMSH2, mutS protein homolog 2
• Host Species: Mouse
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin)
• Clone: 25D12
• Formulation: tissue culture supernatant with 0.09% sodium azide
• Gene Accession No.: P43246
• Gene Symbols: MSH2
• Immunogen: Recombit human MSH2 protein
• Regulatory Status: RUO
• Gene ID (Entrez): 4436
• Content And Storage: 4° C
• Form: Liquid