MLH1 Mouse anti-Human, Clone: ZM001, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen 393200

Product Code. 10494873

Description

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPCC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Specifications

• Antigen: MLH1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Gene: MLH1
• Gene Alias: COCA2, FCC2, HNPCC, HNPCC2, hMLH1, DNA mismatch repair protein Mlh1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4292
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunohistochemistry, Western Blot
• Clone: ZM001
• Conjugate: Unconjugated
• Gene Accession No.: P40692
• Gene Symbols: MLH1
• Immunogen: Recombit protein derived from the C-terminal region of the human MLH1 protein
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ