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Invitrogen™ Anti-miR™ hsa-let-7c miRNA Inhibitor Positive Control
Description
Invitrogen™ Anti-miR™ miRNA Inhibitors are chemically modified, single-stranded nucleic acids designed to specifically bind to and inhibit endogenous microRNA (miRNA) molecules. These ready-to-use inhibitors can be introduced into cells using transfection or electroporation parameters similar to those used for siRNAs. Anti-miR™ let-7c miRNA Inhibitor Positive Control provides a convenient, validated positive control for experiments using Anti-miR miRNA Inhibitors. Endogenous let-7 miRNA negatively regulates HMGA2, a ubiquitously expressed, nonhistone chromatin protein that modulates gene expression through changes in chromatin architecture. When transfected into human and mouse cells, Anti-miR hsa-let-7c miRNA Inhibitor blocks endogenous let-7c miRNA, resulting in increased levels of HMGA2 mRNA.
Accessory Products:
Also available are Anti-miR™ miRNA Inhibitors (SKU #AM17000 and #AM17001). To select your miRNA sequence and order, please visit the GeneAssist™ miRNA Workflow Builder. Anti-miR™ miRNA Inhibitor Negative Control #1 (SKU #AM17010) is a random sequence that has been validated to produce no identifiable effects on known miRNA function. Cy™3 and FAM™ dye-labeled Anti-miR Negative Controls (SKU #AM17011 and #AM17012, respectively) are also available. The Pre-miR™ miRNA Starter Kit (SKU #AM1540) can be used to optimize transfection of Pre-miR™ miRNA Precursors.
Accessory Products:
Also available are Anti-miR™ miRNA Inhibitors (SKU #AM17000 and #AM17001). To select your miRNA sequence and order, please visit the GeneAssist™ miRNA Workflow Builder. Anti-miR™ miRNA Inhibitor Negative Control #1 (SKU #AM17010) is a random sequence that has been validated to produce no identifiable effects on known miRNA function. Cy™3 and FAM™ dye-labeled Anti-miR Negative Controls (SKU #AM17011 and #AM17012, respectively) are also available. The Pre-miR™ miRNA Starter Kit (SKU #AM1540) can be used to optimize transfection of Pre-miR™ miRNA Precursors.
Specifications
Specifications
| Content And Storage | Anti-miR™ miRNA is provided dried down in a single tube, along with Nuclease-free Water for resuspension, and should be stored at –20°C. It is guaranteed for 1 year when stored dried at –20°C. |
| Control Type | Positive Control |
| RNAi Type | miRNA Inhibitor |
| For Use With (Application) | miRNA & Non-Coding RNA Analysis |
| Label or Dye | Unconjugated |
| Product Line | Ambion, Anti-miR |
| Product Type | miRNA Inhibitor |
| Quantity | 5 nmol |
| Shipping Condition | Room Temperature |
For Research Use Only. Not for use in diagnostic procedures.
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