Invitrogen™ mGluR2/mGluR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA536519

Product Code. 15503911

Description

This antibody detects endogenous protein at a molecular weight of 95 kDa. Purity is >95% by SDS-PAGE.

The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.

Specifications

• Antigen: mGluR2/mGluR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Grm2
• Gene Alias: 0710001G23Rik; 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member C; GLUR2; GLUR3; glutamate metabotropic receptor 2; glutamate metabotropic receptor 3; glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; glutamate receptor, metabotropic 3; Gprc1b; GPRC1C; GRM2; Grm3; M mGlu3; Metabotropic glutamate receptor 2; metabotropic glutamate receptor 3; mGlu2; mGlu3; mGluR2; MGLUR3; mGluR7
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108068, 108069, 24415, 24416, 2912, 2913
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P31421, P31422, Q14416, Q14832, Q14BI2, Q9QYS2
• Gene Symbols: Grm2, Grm3
• Immunogen: Synthetic peptide corresponding to amino acids 836-872 of Human mGluR-2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG