mGluR1 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15875729	BD Biosciences 610964	50 μg
15885729	BD Biosciences 610965	150 μg

Description

Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca²⁺ sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca²⁺; mobilization necessary for many signal transduction events.

Immunofluorescence, Western Blotting

Specifications

• Antigen: mGluR1
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified
• Description: Metabotropic Glutamate Receptor-1

• Clone: 20
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Mouse, Rat
• Immunogen: Rat mGluR1 aa. 1042-1160
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.