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Description
The BP-1 antibody reacts with an epitope of the 6C3/BP-1 (Ly-51) glycoprotein cell-surface differentiation antigen, which was originally identified on pre-B cell lymphomas (spontaneous and chemical- or retrovirus- transformed, in vitro and in vivo). 6C3/BP-1 is a homodimer cell-surface glycoprotein with 140kDa subunits which has been identified to possess aminopeptidase A (APA) activity. The same antigen is expressed at high levels on bone marrow stromal cell lines which support in vitro B lymphopoieses, on thymic dendritic cells and cortical epithelial cells, and on a wide variety of mouse and rat tissues known to possess APA activity. Subsets of normal bone marrow pre-B and B lymphocytes express low levels of Ly-51, which is rapidly up-regulated on the pre-B cells in the presence of IL-7. A role for the 6C3/BP-1 molecule in the IL-7-driven proliferation of B cell precursors has been postulated. However, B-cell abnormalities were not detected in Ly-51-deficient mice. Mature B lymphocytes, thymocytes, peripheral T lymphocytes, erythroid cells, and myeloid cells (with the exception of thymic dendritic cells) do not express Ly-51.
Host Species: Mouse
Clone: BP-1
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Abelson murine leukemia virus-transformed BALB/c mouse pre-B cell line 18.81
Flow Cytometry
Specifications
| Ly-51 | |
| Monoclonal | |
| 0.2mg/mL | |
| 6C3/BP-1 Antigen | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| BP-1 | |
| PE | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Abelson murine leukemia virus-transformed BALB/c mouse pre-B cell line 18.81 | |
| 0.2 mg | |
| Immunology | |
| Mouse | |
| IgG2a κ |
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