LOX Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA523001

Product Code. 13278078

Description

The target sequence has 100% sequence homology with rat.

Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin. LOX is synthesized as a 50 kDa precursor, secreted into the extracellular matrix and subsequently proteolytically processed to a 30 kDa active enzyme and an 18 kDa propeptide. LOX also reverts ras-mediated transformation and its expression is down-regulated in human cancers. Most recently, the lysyl oxidase pro-peptide (LOPP) has been associated with tumor suppression, as it inhibits ras-dependent cellular transformation.

Specifications

• Antigen: LOX
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: P28300, P28301
• Gene Symbols: LOX
• Immunogen: A synthetic peptide made to an internal region of mouse LOX propeptide (within residues 135-155).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Gene: LOX
• Gene Alias: protein-lysine 6-oxidase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16948, 4015
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid