LDHA Mouse anti-Human, Mouse, Rat, Clone: AF14A11, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA517247

Produktkod. 15328230

Beskrivning

A suggested positive control for this product is HeLa cells.

Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84-89% sequence similarities and 69-75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers.

Specifikationer

• Antigen: LDHA
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: HEPES with 0.01% BSA, 0.15M NaCl, 50% glycerol and 0.03% sodium azide
• Gene Accession No.: P00338, P06151, P04642
• Gene Symbols: LDHA
• Immunogen: Recombit human protein purified from E.coli (His-LDHA)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Immunoprecipitation, Western Blot
• Clone: AF14A11
• Conjugate: Unconjugated
• Gene: LDHA
• Gene Alias: PIG19; GSD11; LDH1; LDHM; L-lactate dehydrogenase A chain; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protein; lactate dehydrogenase M; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 16828, 24533, 3939
• Content And Storage: -20°C
• Form: Liquid