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Lck Alexa Fluor 647 Monoclonal Antibody, Clone: LCK-01, Invitrogen™

Lck Antibody, Alexa Fluor 647 conjugate (LCK-01), MA5-18166, from Invitrogen™. Species Reactivity: Human; Applications: Flow Cytometry.

Brand:  Invitrogen MA518166

UNSPSC : 12352203

Code : NEW

Additional Details : Weight : 0.01000kg

Product Code. 15337434

  • £330.00 / 100µg


Estimated Shipment
11-10-2017
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Description

Description

Lck is a Src-family tyrosine kinase, which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, Lck phosphorylates the ITAM motives in its zeta subunits, establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane, there is also a significant fraction associated with the Golgi apparatus, which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG1
Clone: LCK-01
Immunogen: Peptide corresponding to amino acids 22-36 in the sequence of human Lck
Formulation: 100μg purified antibody (1mg/mL) in PBS and 15mM sodium azide; pH 7.4
Synonyms: RP4-675E8.4, LSK, YT16, p56lck, pp58lck, T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; tyrosine-protein kinase Lck
Uniprot Accession: P06239
Entrez GeneID: 3932
Gene Symbol: LCK
This antibody will not cross-react with mouse.
Specifications

Specifications

Lck
LCK-01
100μg purified antibody (1mg/mL) in PBS and 15mM sodium azide; pH 7.4
Purified
LCK
Peptide corresponding to amino acids 22-36 in the sequence of human Lck
100μg
Primary
3932
Flow Cytometry
Alexa Fluor™ 647
P06239
RP4-675E8.4, LSK, YT16, p56lck, pp58lck, T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; tyrosine-protein kinase Lck
Murine
IgG1
DO NOT FREEZE!
Monoclonal
Human