Lck Alexa Fluor 647 Monoclonal Antibody, Clone: LCK-01, Invitrogen™

Lck Antibody, Alexa Fluor 647 conjugate (LCK-01), MA5-18166, from Invitrogen™. Species Reactivity: Human; Applications: Flow Cytometry.

Overview
Brand: Invitrogen

Manufacturer Part Number: MA518166

UNSPSC: 12352203

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 15337434

Quantity Price
1 £ 330.0 / 100µg
Estimated Shipment date
from Supplier 12-04-2017
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Description and Specification

Specification

Conjugate Alexa Fluor 647
Formulation 100μg purified antibody (1mg/mL) in PBS and 15mM sodium azide; pH 7.4
Gene ID (Entrez) 3932
Cross Reactivity Human
Antigen Lck
Storage Requirements DO NOT FREEZE!
Isotype IgG1
Immunogen Peptide corresponding to amino acids 22-36 in the sequence of human Lck
Primary or Secondary Primary
Format Purified
Clone LCK-01
Gene Accession No. P06239
Host Species Mouse
Species Reactivity Human
Quantity 100μg
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Gene Alias RP4-675E8.4, LSK, YT16, p56lck, pp58lck, T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; tyrosine-protein kinase Lck
Gene Symbols LCK

Lck is a Src-family tyrosine kinase, which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, Lck phosphorylates the ITAM motives in its zeta subunits, establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane, there is also a significant fraction associated with the Golgi apparatus, which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG1
Clone: LCK-01
Immunogen: Peptide corresponding to amino acids 22-36 in the sequence of human Lck
Formulation: 100μg purified antibody (1mg/mL) in PBS and 15mM sodium azide; pH 7.4
Synonyms: RP4-675E8.4, LSK, YT16, p56lck, pp58lck, T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; tyrosine-protein kinase Lck
Uniprot Accession: P06239
Entrez GeneID: 3932
Gene Symbol: LCK
This antibody will not cross-react with mouse.