KLRG1 Hamster anti-Mouse, NA/LE, Unlabeled, Clone: 2F1, BD

Hamster Monoclonal Antibody

Brand:  BD Biosciences 562190

Product Code. 15881709

Description

The 2F1 monoclonal antibody specifically binds to KLRG1 (Killer cell Lectin-like Receptor mmunoreceptor Tyrosine-based Inhibitory Motif);its ligand has not beenidentified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Cross-linking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++mobilization and cytotoxic responses (but not IFN-γ production) by CD8+ T cellsand inhibits IFN-γ and TNF-αproduction and redirected lysis by NK cells.

Specifications

• Antigen: KLRG1
• Classification: Monoclonal
• Concentration: 1.0mg/mL
• Description: Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA
• Host Species: Hamster
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG2 κ

• Applications: Flow Cytometry
• Clone: 2F1
• Conjugate: Unconjugated
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Immunogen: A-LAK from C57BL/6 mice
• Quantity: 0.5 mg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C