KEAP1 Polyclonal Antibody, Invitrogen™
KEAP1 Antibody, PA5-34454, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: Immunofluorescence, Western Blot.
Brand: Invitrogen PA534454
Code : NEW
Additional Details : Weight : 0.01000kg
DescriptionKEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-Kappa-B activity by targeting IKKBeta degradation. Mutation of the KEAP1 gene is found in lung cancer.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Immunogen: A 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1
Formulation: 100 ug purified antibody (1mg/mL) in PBS and 0.02% sodium azide
Synonyms: KEAP1, Kelch-like ECH-associated protein 1, INRF2, Kelch-like protein 19, KLHL19, Cytosolic inhibitor of NRF2
Uniprot Accession: P57790, Q14145, Q9Z2X8
Entrez GeneID: 117519, 50868, 9817
Gene Symbol: KEAP1
A suggested positive control is human lung tissue lysate. PA5-34454 can be used with blocking peptide PEP-1496.
|P57790, Q14145, Q9Z2X8|
|KEAP1, Kelch-like ECH-associated protein 1, INRF2, Kelch-like protein 19, KLHL19, Cytosolic inhibitor of NRF2|
|Store at 2-8°C for up to 3 months. For long term storage store at -20°C|
|100μg purified antibody (1mg/mL) in PBS and 0.02% sodium azide|
|A 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1|
|117519, 50868, 9817|