KEAP1 Polyclonal Antibody, Invitrogen™

KEAP1 Antibody, PA5-34454, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: Immunofluorescence, Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA5-34454

Polyclonal Antibody, KEAP1, host Rabbitisotype IgG

UNSPSC: 12352203

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 15355381

Quantity Price
1 £ 317.0 / 100µg
Estimated Shipment date
from Supplier 23-12-2016
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Description and Specification

Specification

Antigen KEAP1
Applications Immunofluorescence
Applications Immunohistochemistry
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Formulation 100μg purified antibody (1mg/mL) in PBS and 0.02% sodium azide
Gene Accession No. P57790, Q14145, Q9Z2X8
Gene Alias KEAP1, Kelch-like ECH-associated protein 1, INRF2, Kelch-like protein 19, KLHL19, Cytosolic inhibitor of NRF2
Gene Symbols KEAP1
Host Species Rabbit
Immunogen A 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1
Isotype IgG
Quantity 100μg
Species Reactivity Human, Mouse, Rat
Storage Requirements Store at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 117519, 50868, 9817

KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-Kappa-B activity by targeting IKKBeta degradation. Mutation of the KEAP1 gene is found in lung cancer.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: A 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1
Formulation: 100 ug purified antibody (1mg/mL) in PBS and 0.02% sodium azide
Synonyms: KEAP1, Kelch-like ECH-associated protein 1, INRF2, Kelch-like protein 19, KLHL19, Cytosolic inhibitor of NRF2
Uniprot Accession: P57790, Q14145, Q9Z2X8
Entrez GeneID: 117519, 50868, 9817
Gene Symbol: KEAP1
A suggested positive control is human lung tissue lysate. PA5-34454 can be used with blocking peptide PEP-1496.